Clinical Trials

A clinical study is a type of medical research that involves people who volunteer to take part. Clinical studies help researchers learn more about pulmonary hypertension (PH), how it affects people, and how it can be diagnosed and treated.

There are two main types of clinical studies:

Clinical trials (interventional studies): Researchers test a treatment, medicine, or other approach to learn how it affects people with pulmonary hypertension.

Observational studies: Researchers collect information about people with pulmonary hypertension without giving them a specific treatment as part of the study. This can help researchers better understand the disease, how it changes over time, and how it affects patients’ lives.

Both types of studies are important. They help researchers better understand pulmonary hypertension and work toward improving care and developing new treatment options for people living with PH.

Match to PH Clinical Trials Now

Antidote Match™ makes it easier to find medical research studies that may be a match for you. Simply answer a few questions, and you’ll quickly see clinical trials that may fit your needs.

Ready to get started? Click START below to search for Pulmonary Hypertension clinical trials near you. Then click SUBMIT in the next window to see currently active studies in your area.

You can also explore clinical trials related to other lung and connective tissue conditions, including:

Asthma · COPD · Emphysema · Idiopathic Pulmonary Fibrosis (IPF) · Interstitial Lung Diseases · Sarcoidosis · Scleroderma

Your participation in research could help advance what we know about these conditions and help shape the treatments of tomorrow.

About Clinical Trials

Finding new medicines and treatments takes time. Before a new medicine can become available to the public, it goes through a careful process of research and testing called drug development.

One important part of this process is the clinical trial, also called a clinical study. This is when researchers study a potential new medicine in people to learn more about how it works, how it affects the body, and whether it may be safe and effective.

Clinical trials rely on people who volunteer to participate. Volunteers work with doctors and research teams, who carefully monitor their health and collect information throughout the study. Every clinical trial is different, and people may participate for different reasons, including the opportunity to contribute to research and help advance treatment options for others.

Before a medicine can be approved and made available to the public, it is studied in clinical trials involving many people, sometimes hundreds or even thousands of volunteers.

Without volunteers, clinical research would not be possible. By choosing to participate, volunteers make an important contribution to medical research and help researchers learn more about new medicines and potential treatments for people today and in the future.

Phases of a Clinical Trial

Clinical trials are usually conducted in several phases. Each phase has a different purpose and helps researchers learn more about a potential new medicine, including how it works, how safe it may be, and whether it may help people with a particular disease or condition.

Clinical trials generally progress from Phase I to Phase III, although some medicines may follow a different path depending on the type of medicine and the condition being studied. If a medicine is approved and becomes available to patients, researchers may continue studying it in Phase IV.

Phase I: Is it safe?

Phase I is usually the first time a potential new medicine is tested in people. These studies typically involve a small number of volunteers and focus primarily on safety. Researchers carefully monitor participants to understand how the medicine affects the body, determine appropriate doses, and identify possible side effects.

Phase I studies may include healthy volunteers or people with the disease or condition being studied, depending on the medicine and the research.

Phase II: Does it show promise?

Phase II studies usually involve more people who have the disease or condition the medicine is intended to treat. Researchers continue to study safety and side effects while looking for early evidence that the medicine may help patients.

Researchers also use this phase to learn more about the best dose and how the medicine affects people with the condition.

Phase III: Does it work and is it safe?

Phase III studies involve a larger number of patients and provide more information about the medicine's safety and effectiveness. Researchers may compare the potential new medicine with a placebo, an existing treatment, or another approach, depending on the study.

The information collected during Phase III can be an important part of the evidence submitted to regulatory agencies when seeking approval for the medicine.

Phase IV: What can we learn after approval?

Clinical research does not necessarily end when a medicine is approved. In Phase IV, researchers may continue to study an approved medicine in people who use it as part of their care.

These studies, sometimes called post-marketing studies, can help researchers learn more about the medicine over time, including its long-term safety, effectiveness, and how it works in a broader population of patients.